The following is a ranking of all banks in the United States in terms of "Loans and leases, gross". This comparison is based on data reported on 2020-12-31.
| Rank | Loans and leases, gross | Bank Name |
| 1 | $255,471,000,000 | Citibank |
| 2 | $116,672,000,000 | JPMorgan Chase Bank |
| 3 | $86,070,000,000 | Bank of America |
| 4 | $37,628,000,000 | Wells Fargo Bank |
| 5 | $9,749,000,000 | The Bank of New York Mellon |
| 6 | $8,450,538,000 | Capital One Bank (USA) |
| 7 | $5,031,000,000 | Banco Popular de Puerto Rico |
| 8 | $5,009,015,000 | Silicon Valley Bank |
| 9 | $3,619,202,000 | PNC Bank |
| 10 | $2,940,000,000 | State Street Bank and Trust Company |
| 11 | $1,500,568,000 | East West Bank |
| 12 | $1,238,170,000 | Bank of China |
| 13 | $1,181,939,000 | Raymond James Bank |
| 14 | $1,149,032,000 | The Northern Trust Company |
| 15 | $628,354,000 | Bank of Hawaii |
| 16 | $616,795,000 | First Hawaiian Bank |
| 17 | $616,402,000 | Lake Forest Bank & Trust Company |
| 18 | $393,196,000 | Fifth Third Bank |
| 19 | $387,240,000 | U.S. Bank |
| 20 | $367,000,000 | Comerica Bank |
| 21 | $325,571,000 | Safra National Bank of New York |
| 22 | $317,000,000 | Truist Bank |
| 23 | $280,255,000 | Cathay Bank |
| 24 | $273,553,000 | TCF National Bank |
| 25 | $243,216,000 | Banesco USA |
| 26 | $151,046,000 | FirstBank Puerto Rico |
| 27 | $149,374,000 | Manufacturers and Traders Trust Company |
| 28 | $90,412,000 | WEX Bank |
| 29 | $81,733,000 | Bank of Guam |
| 30 | $61,430,000 | KeyBank |
| 31 | $30,000,000 | Mizuho Bank (USA) |
| 32 | $28,778,000 | Bank of the Orient |
| 33 | $25,676,000 | Habib American Bank |
| 34 | $10,172,000 | Finance Factors, Ltd. |
| 35 | $6,753,000 | Capital One |
| 36 | $2,331,000 | BankPacific, Ltd |
| 37 | $1,000 | HSBC Bank USA |
| 38 | $0 | Amerant Bank |
| 38 | $0 | 1st Financial Bank USA |
| 38 | $0 | Ally Bank |
| 38 | $0 | American Express National Bank |
| 38 | $0 | Associated Bank |
| 38 | $0 | BAC Florida Bank |
| 38 | $0 | Bank Hapoalim B.M. |
| 38 | $0 | Bank Leumi USA |
| 38 | $0 | Bank of America California |
| 38 | $0 | Bank of Baroda |
| 38 | $0 | Bank of India |
| 38 | $0 | Bank of the West |
| 38 | $0 | BMO Harris Bank |
| 38 | $0 | BNY Mellon Trust of Delaware |
| 38 | $0 | BNY Mellon |
| 38 | $0 | Charles Schwab Bank, SSB |
| 38 | $0 | Charles Schwab Premier Bank, SSB |
| 38 | $0 | Charles Schwab Trust Bank |
| 38 | $0 | Citizens Bank |
| 38 | $0 | City National Bank |
| 38 | $0 | Delta National Bank and Trust Company |
| 38 | $0 | Department Stores National Bank |
| 38 | $0 | Discover Bank |
| 38 | $0 | Eastern National Bank |
| 38 | $0 | First Midwest Bank |
| 38 | $0 | First Republic Bank |
| 38 | $0 | Goldman Sachs Bank USA |
| 38 | $0 | Interaudi Bank |
| 38 | $0 | JPMorgan Chase Bank, Dearborn |
| 38 | $0 | Metropolitan Bank and Trust Company |
| 38 | $0 | Mizrahi Tefahot Bank, Ltd. |
| 38 | $0 | Morgan Stanley Bank |
| 38 | $0 | Morgan Stanley Private Bank |
| 38 | $0 | MUFG Union Bank |
| 38 | $0 | Old National Bank |
| 38 | $0 | Regions Bank |
| 38 | $0 | Santander Bank, N.A. |
| 38 | $0 | State Bank of India |
| 38 | $0 | State Bank of India |
| 38 | $0 | Sumitomo Mitsui Trust Bank (U.S.A.) Limited |
| 38 | $0 | TD Bank |
| 38 | $0 | The Bank of East Asia Ltd. |
| 38 | $0 | The Bank of New York Mellon Trust Company |
| 38 | $0 | The Huntington National Bank |
| 38 | $0 | The National Bank of Indianapolis |
| 38 | $0 | U. S. Century Bank |
| 38 | $0 | Webster Bank |
| 38 | $0 | Wells Fargo Bank South Central |
| 38 | $0 | Wells Fargo National Bank West |
| 87 | $-1,000 | Falcon International Bank |
